Sodium--potassium pump current in rabbit sino-atrial node cells.
نویسندگان
چکیده
منابع مشابه
Current-dependent Block of Rabbit Sino-Atrial Node If Channels by Ivabradine
"Funny" (f-) channels have a key role in generation of spontaneous activity of pacemaker cells and mediate autonomic control of cardiac rate; f-channels and the related neuronal h-channels are composed of hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel subunits. We have investigated the block of f-channels of rabbit cardiac sino-atrial node cells by ivabradine, a novel heart ...
متن کاملThe effects of extracellular calcium removal on sino-atrial node cells treated with potassium-depleted solutions.
The effect of extreme calcium reduction was studied in rabbit sino-atrial node cells treated with K-free media. Ca removal (Ca = 0, EGTA = 6 mM) suppressed spontaneous miniature fluctuations elicited by exposure to the K-free media. Further, successive exposure to the Ca-free, EGTA solutions produced a propagated action potential and suppressed a contracture. The action potential was not notice...
متن کاملFacilitation of the L-type calcium current in rabbit sino-atrial cells: effect on cardiac automaticity.
OBJECTIVE The L-type Ca(2+) current (I(Ca,L)) contributes to the generation and modulation of the pacemaker action potential (AP). We investigated facilitation of I(Ca,L) in sino-atrial cells. METHODS Facilitation was studied in regularly-beating cells isolated enzymatically from young albino rabbits (0.8-1 kg). We used the whole-cell patch-clamp technique to vary the frequency of the test de...
متن کاملInhibition by genistein of the hyperpolarization-activated cation current in porcine sino-atrial node cells.
1 The hyperpolarization-activated cation current (If) was recorded in single pacemaker cells of the porcine sino-atrial node, and the effects of genistein, an isoflavone inhibitor of tyrosine-specific protein kinases was investigated by the whole-cell patch clamp technique. 2 Genistein (20-500 microM) decreased If in a dose-dependent manner with an IC50 value of 62.3 microM and a maximum inhibi...
متن کاملPacemaker mechanism of porcine sino-atrial node cells.
In cardiac sino-atrial node (SAN) cells, time- and voltage-dependent changes in the gating of various ionic currents provide spontaneous, stable and repetitive firing of action potentials. To address the ionic nature of the species-dependent heart rate, action potentials and membrane currents were recorded in single cells dissociated from the porcine SAN, and compared with those from SAN cells ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1996
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1996.sp021126